IRE well positioned to develop waste-free, non-fission medical isotopes

IRE signs agreement with ASML and receives subsidy from Belgian Federal Government

IRE (Institut National des Radioéléments, Fleurus, Belgium) has entered into a joint development agreement with ASML (one of the world’s leading manufacturers of chip-making equipment). The agreement will allow IRE with the support of ASML to further develop and build an electron beamline that will be used to manufacture the medical isotope molybdenum 99 (Mo-99) in a new production process that is non-fission and waste-free.  Mo-99 is used for diagnosing tens of millions people annually, making it the most commonly used medical radioisotope.

The agreement includes multi-year technology support by ASML experts and use of IP. In addition, the Belgium federal government has approved a subsidy of up to 52 million euros for the development phase (design and testing) of the technology, which will take place during 2018 till 2020.

Erich Kollegger, General Manager of IRE says: “We are excited about this innovative technology and IRE envisages to use this beamline for all our demand for the medical isotope Mo-99, phasing out the fission-based production process.  We plan to start building the facility in the course of 2020 at our site in Fleurus and expect to start production of Mo-99 in 2024.”

Frits van Hout, Executive Vice President and Chief Strategy Officer at ASML adds: “Since we are a semiconductor equipment company, medical isotopes do not fit our strategy. Nevertheless, we did not want to shelve our invention and have been looking for a suitable partner for some time, inside and outside of the Netherlands. We are grateful to the Dutch Ministry of Economic Affairs for naming this innovative technology (LightHouse) a National Icon in 2016. This gave us the support and visibility we needed. We are proud to now make the technology available to IRE.”

About IRE

IRE, the Institut National des Radioéléments, is a public utility foundation whose main activity is the production of radioisotopes for diagnostic and therapeutic applications in the area of nuclear medicine. It is a global leader in the production of Molybdenum-99, the “parent” isotope of metastable Technetium-99 and the most widely used in nuclear medicine for numerous examinations (heart, bones, lungs, thyroid, brain, kidneys, etc.).
Further information is available at www.ire.eu

About ASML

ASML is one of the world’s leading manufacturers of chip-making equipment. Our vision is a world in which semiconductor technology is everywhere and helps to tackle society’s toughest challenges. We contribute to this goal by creating products and services that let chipmakers define the patterns that integrated circuits are made of. We continuously raise the capabilities of our products, enabling our customers to increase the value and reduce the cost of chips. By helping to make chips cheaper and more powerful, we help to make semiconductor technology more attractive for a larger range of products and services, which in turn enables progress in fields such as healthcare, energy, mobility and entertainment. ASML is a multinational company with offices in 60 cities in 16 countries, headquartered in Veldhoven, the Netherlands. We employ more than 21,000 people on payroll and flexible contracts (expressed in full time equivalents). ASML is traded on Euronext Amsterdam and NASDAQ under the symbol ASML. More information about ASML, our products and technology, and career opportunities is available on www.asml.com.

Bérénice Pignol

IRE - IRE ELiT

Ariane Goossens

Whyte Corporate Affairs

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About IRE and IRE ELiT

Founded in 1971 and based in Fleurus, in the province of Hainaut, the National Institute of Radioelements (IRE), a Belgian foundation of public interest, is one of the very few players worldwide capable of producing and developing certain radioisotopes used in nuclear medicine.

IRE is notably the global leader in the production of Molybdenum‑99, the “parent” isotope of metastable Technetium-99m. Using a gamma camera, this isotope makes it possible to observe a patient’s internal anatomy in real time (heart, bones, lungs, thyroid, brain, kidneys, etc.) and to diagnose certain diseases at an early stage. IRE supplies around 50% of European demand for Mo-99 and 25% of global production, a share that can rise to up to 65% during periods of global supply tension.

At the same time, IRE ELiT, a subsidiary founded in 2010, is one of the two global leaders in pharmaceutical‑grade Ge-68/Ga-68 generators for human use. Gallium-68 (Ga-68) is a key isotope for high‑precision PET imaging - particularly for neuroendocrine tumours and prostate cancer - and for personalised medicine in radioligand therapy (RLT) strategies. IRE-ELiT’s Ga-68 generators are currently marketed in around 40 countries.

Beyond its production activities aimed at improving patient care and quality of life, IRE also contributes - through its IRE Lab division - to environmental protection and monitoring. The Institute offers services for radioactivity measurement in various samples, radiological characterisation of waste and contaminated materials, as well as consultancy and technical support in the radiological and nuclear fields.

Today, IRE and IRE ELiT employ 300 people, all committed to translating cutting‑edge scientific advances into diagnostic and therapeutic solutions for patients.

More information: www.ire.eu

Contact

www.ire.eu